Diagnostics Derived from Extracellular Vesicles

Development PhasesIn this article, lead author Anudeep Yekula and co-authors from Ceres describe the process of developing clinical diagnostics based on extracellular vesicles.

Complexities in this process derive from the need to standardize the isolation, characterization, and biofluid sampling protocols when working with EVs. In a recent NIH R01 grant to the Ceres Lab, we are undertaking a series of studies to i) address variability among the different EV isolation methods and platforms currently available, and to ii) pinpoint to the “best” method to validate candidate biomarkers for glioma diagnosis.